Mucormycosis (phycomycosis)

Mucormycosis (phycomycosis)

• rare
• very aggressive life-threatening fungal infection
• Mucor spp. or Rhizopus.
• in immunosuppressed, DKA or RF .
• elderly, malignancy, AIDS.
• fungal septic necrosis and infarction of tissues of nasopharynx and orbit.

Clinical features for Mucormycosis (phycomycosis)

• Black crusty material in nasopharynx
• cranial nerve palsies (III, IV, V, VI, IIn)
• obvious orbital inflammation.

Investigation for Mucormycosis (phycomycosis)

• Biopsy: fungal stains (non-septate branching hyphae) 
• FBC, U/E ,Glu.
• CT is a must in all cases of coma with Diabetic ketoacidosis 

Treatment for Mucormycosis (phycomycosis)

• Admit, liaise with microbiologist, ENT specialist ± physician.
• Correct underlying disease (diabetic ketoacidosis) where possible, without this, the prognosis is extremely poor.
• IV antifungals (guided by microbiology,high-dose amphotericin).
• Some advocate hyperbaric oxygen therapy.
• early and aggressive surgical debridement by ENT specialist ± orbital exenteration (for severe or unresponsive disease).

Mucormycosis (phycomycosis) power point presentations:

Mucormycosis

1. MUCORMYCOSISPRESENTED BY -DR SANTOSH M NARAYANKAR
2. MUCOR MYCOSIS REFERS TO…… infection caused by fungi in order of mucorales . Most common species are…rhizopus (m c),rhizomucor,cunninghamella,apophysomy ces,saksenaea,absidia,muccor,andsyncephal astrum.
3. MUCORMYCOSISMucor species Rhizopus sp
4. MAJOR ROUTE OF INFECTION INHALTION. INGESTION. TRAUMATIC INOCULTION.
5. Pathophysiology Angioinvasion Vessel thrombosis Tissue necrosis
6. EPIDEMIOLOGY INTERNATIONALY 1% PATIENTS WITH LOW IMMUNITY. MUCOR MYCOSIS CARRIES A VERY HIGH MORTALITY (50%-85%). NO RACIAL FACTORS PREDISPOSE. SEX IS NOT LIKELY TO AFFECT.
7. MUCORMYCOSIS CLINICAL PRESNTATION Five clinical forms of mucormycosis : Rhinocerebral ,pulmonary ,gastrointestinal , primary cutaneouse and disseminated. Rhinocerebral type has the highest frequency and mortality.

Mucormycosis

1. 1. By, SATHYA.T MSC Microbiology, (2017-2019) Tirupur kumaran college for women, Tirupur.
2. Kingdom: Fungi Division: Zygomycota  Class: Mucormycotina  Order: Mucorales  Family: Mucoraceae  Genus: Mucor
3. Sabouraud dextrose agar medium Potato dextrose agar medium
4. Take place in *vegetative reproduction *Sexual reproduction *Asexual reproduction
5. It consists of mother mycelium  Each fragments can split into many sub- units.  Each sub-units have a capability to grow like new mycelium.  Like fragmentation methods.
6. It mainly takes in three spores. 1) Sporangiospores 2) Chlamydospores 3) Oidio spores. SPORANGIOSPORES: It takes place by steps: sporangiopores englongation Columenllaplasm bursting germination
7. →Opportunistic infection of sinuses , nasal passages , oral cavity. →Rapid death. →Grow rapidly and release air- borne spores. →Enter through nose, oral mucosa and throat. →Attack immunelow peoples.
8. Risk factors: →Diabetes Mellitus →Burns →Iron overload →Transplantation →Chemotheraphy →Intravenous drug use
9. Rare diseases occur in patients who have prolonged neutropaenia.  Treatment with deferoxamine  Indistinguishable from Invasive Pulmonary Aspegillosis.  Symptoms: fever , Cough , dyspnoea, Chest Pain, Pleural effusion.  Species: Mucormycotina  Spores -3 to 11 µm.  Routes: Inhalation , cutaneous …
10. Life-threatning diseases.  Specimen: Nasal Seceations.  Drug: amphotericin B ( sideeffects)  Treatment: antifungal theraphy.
11. Transmission: Inhalation of spores.  Common in children.  Affects Immuno-comprised patients.  Symptoms varies depend upon the part of the body.  Common Symptoms: abdominal pain, Bowel Obstruction, Vomiting , Bloody diarrhea,Dyspepsia.  Prognosis is very poor.
12. Rare, fatal complication disease.  Multiorgans manifestations.  Symptoms: mental status changes.  Occur who are already sick from medical condition.  Leads to coma.
13. *Reddish and swollen skin, skin trauma, ulcer. *mainly painful patches of skin. * fungal enter through skin. *patients who are low Ig A and IgG antibodies. *skin theraphy , transplantation.
14. *Very poor *Surgery can done depend upon area
15. Antifungal medicine, usually amphotericin B, through a vein.
16. For listening angels…

Mucormycosis (phycomycosis) Videos:

Mucor and Mucormycosis – YouTube

Mucormycosis ¦ Treatment and Symptoms – YouTube

Mucormycosis (phycomycosis)