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Diabetic microangiopathy occurs at the level of capillaries in 2 stages
✅ Capillaropathy in The pathogenesis of diabetic microangiopathy.
✍️ Degeneration and loss of pericytes
✍️ Proliferation of endothelial cells
✍️ Thickening of basement membrane
✍️ capillaries occlusion
✅ Hematological changes in The pathogenesis of diabetic microangiopathy:
✍️ Deformation of erythrocytes
✍️ rouleaux formation
✍️ abnormal RBC with defective oxygen transport
✍️ Increased plasma viscosity
✍️ stickiness and aggregation of platelets.
These capillaries and hematological changes result in microvascular occlusion and leakage and exudates